Dermal fillers: a patient guide to hyaluronic acid
What hyaluronic acid dermal fillers are, which areas they treat, how long they last, how they are reversed and what the real risks are in Spain.
7 min readEducational content by RejuvelookUpdated in October 2026
In short
Dermal fillers are CE-marked hyaluronic acid gels a doctor injects to restore support, define a contour or soften a fold. The effect is temporary and depends on the area, from about a year in the lips to up to two years in the cheeks. They can be dissolved with an enzyme. Serious complications are rare but need a prepared doctor.
Key points
- In a meta-analysis of lip filler, 74% still had fuller lips at six months and 46% at one year.
- In a randomised trial of cheek filler, nearly half of those treated kept the correction for 24 months.
- Across 290,307 injections in one group of clinics, serious complications occurred in 0.0041%.
- Delayed lumps appeared in about 1% of treatments in one clinic's six-year follow-up, on average 144 days later.
- Hyaluronic acid can be dissolved with an enzyme. Permanent fillers cannot.
Dermal fillers are among the most common treatments in aesthetic medicine, and among the most misunderstood. Used well, they restore what the face loses with time and nobody notices them. Used carelessly, they are what people picture when they think of an "overdone" face. This guide explains what hyaluronic acid fillers are, which areas they treat, how long they last and what the real risks are, whether you live on the Costa del Sol or spend the winter here.
What dermal fillers are
Hyaluronic acid is a substance your body makes naturally. It holds water in the skin and the tissues beneath it. Dermal fillers are gels of hyaluronic acid that has been cross-linked, which means its chains are bonded together so the gel lasts months rather than days. In Europe they are regulated as medical devices and must carry a CE mark.
Not all gels are the same. Some are firm and cohesive, designed to sit on the bone and give structure, as in the cheeks, chin or jawline. Others are soft and flexible, designed to blend into the lips or fine lines, or to hydrate the skin. Choosing the right gel, the right depth and the right amount is a large part of what separates a natural result from one that shows.
Hyaluronic acid has two practical advantages. Because the body already contains it, true allergic reactions are very unusual. And it can be broken down quickly by injecting an enzyme, so the treatment is reversible [1].
Which areas they treat
Fillers are rarely about filling a line. More often they restore support that has been lost, so the face holds its shape again. The areas most often treated are:
- Cheeks. Restoring volume over the cheekbone supports the midface. It can also soften the tear trough and the nasolabial folds indirectly.
- Temples. Hollow temples make the face look drawn and narrow at the top. A small amount of filler can rebalance the upper face.
- Nasolabial folds. The fold from the side of the nose to the corner of the mouth. Often the cheek is treated first and the fold only if something remains.
- Marionette lines. The folds running down from the corners of the mouth, which can make you look sad or cross at rest.
- Lips. Volume, definition or hydration, in proportion with your face. Read more in our guide to lip filler.
- Tear trough. The hollow between the lower eyelid and the cheek. It only helps one type of dark circle, as we explain in dark circles and tear trough filler.
- Chin and jawline. Projecting the chin or defining the jaw can rebalance the profile and the lower face. We cover this in jawline filler and ageing.
How you are assessed
A good consultation starts with your whole face, not the line that bothers you. The doctor looks at your face at rest and in movement, from the front and in profile. Often the fold you point to is the consequence of lost support somewhere else.
You will be asked about your health, your medicines, allergies, autoimmune conditions, cold sores and any previous filler. If you have had filler before, try to find out what it was. A permanent filler changes the plan completely.
The doctor should then explain which areas, if any, are worth treating, with which type of product and in what order. Sometimes the honest answer is that a filler is not what you need.
How long dermal fillers last, by area
You see a change straight away. Swelling exaggerates it for the first days, so the real result is the one you see at two to three weeks.
After that, the gel is gradually absorbed. How quickly depends on the product, the area, the amount and how much the area moves. The studies give an idea:
- Lips. In a meta-analysis, 91% still had fuller lips at two months, 74% at six months and 46% at one year [3].
- Tear trough. A systematic review found that the effect lasted 8 to 12 months [4].
- Cheeks. In a randomised trial with a firm volumising gel, 85.6% had improved at six months and nearly half kept the correction for 24 months [2].
As a general rule, deep areas of support such as the cheeks, chin and jawline hold longer than areas that move constantly, such as the lips. Many people keep their result with a smaller top-up rather than starting again from nothing.
What to expect, realistically
- A fresher, more rested face, with better support and softer folds.
- Changes that are measured and in proportion, not a different face.
- Some swelling, and possibly a bruise, for a few days.
- A review at two to three weeks to decide whether a small adjustment is needed.
Fillers do not lift heavy, loose skin, and they do not replace a facelift when there is a lot of laxity. If that is your situation, a good doctor will say so.
Risks, and who should not have them
Most side effects are expected and short-lived: tenderness, swelling, redness and bruising at the injection points. They settle on their own within days.
Less often there can be lumps, irregularities, a bluish tinge under thin skin or an infection. An expert consensus led by Spanish doctors classifies these complications by when they appear, from the first hours to months later, and sets out how to treat each one [7]. Lumps can appear late. In one clinic's six-year follow-up of 673 treatments, delayed inflammatory lumps occurred in about 1%, on average 144 days after the injection [8].
The most serious complication is vascular occlusion: filler entering or pressing on a blood vessel and cutting off blood supply to the skin. Across 290,307 injections in one group of clinics, serious complications occurred in 0.0041%, and most vascular cases followed injections in the forehead [5]. Rare does not mean impossible. That is why the consensus recommends emergency protocols with the right agents ready in the clinic [7].
Loss of vision is exceptional. In a systematic review, it was nearly always immediate, and the nose, the area between the brows and the forehead were the areas most often involved. No cases were reported from the lips, chin or jawline [6]. Volumes as small as 0.2 ml have been enough to cause it, which is why technique and anatomy matter even with small amounts [6].
Permanent fillers. Some products, such as liquid silicone and certain synthetic gels, are not absorbed. They cannot be dissolved, and reactions to them can appear years later and may need surgery to remove. We do not recommend them.
Who should not have fillers: anyone pregnant or breastfeeding, with an active infection or cold sore in the area, an uncontrolled autoimmune condition, a known allergy to a component, or a previous severe reaction to filler. Blood thinners and bleeding disorders need to be discussed first: do not stop any medicine on your own.
Why a doctor and a healthcare setting matter in Spain
In Spain, dermal fillers are a medical procedure. A doctor indicates them and is responsible for them, and they are given in a licensed healthcare centre, not a beauty salon or a hotel room. Whether you are looking for dermal fillers in Marbella, Malaga or anywhere else on the Costa del Sol, check that the clinic has a healthcare registration number, that a registered doctor treats you, and that you are told the product name and batch number.
Ask what would happen if a complication occurred, and whether the enzyme that dissolves hyaluronic acid is kept on site. If you are here for the season, plan treatment so the review falls before you fly home.
How we approach it at Rejuvelook
At our clinic in Fuengirola, a doctor sees you first for a medical consultation of your face as a whole. If dermal fillers suit you, we explain which areas we would treat, which type of hyaluronic acid we suggest and why, and what change is reasonable. We work with conservative amounts, record the product and batch in your notes and review the result once it has settled. We do not use permanent fillers. If a filler is not what your face needs, we will tell you. We see patients in English or Spanish.
What the evidence says
Each statement shows its level of evidence and the sources behind it.
Supported
With caveats
- How long the effect lasts depends on the area: 8 to 12 months under the eyes, fewer than half keep it at one year in the lips, nearly half keep it at two years in the cheeks.[4][3][2]Moderate evidence
- Most side effects are mild and short-lived. Serious complications are rare, and protocols with the right agents on site reduce their severity.[5][7]Moderate evidence
Not enough support
- Vision loss is known from published cases: it is concentrated around the nose, between the brows and the forehead, with none reported from the lips, chin or jawline.[6]Low-quality evidence
- Delayed inflammatory lumps occurred in about 1% of treatments in a single-centre series; larger studies are needed.[8]Low-quality evidence
When to see a doctor
Book a medical consultation, or go to A&E if it is severe or sudden, if you notice:
- Severe or increasing pain, paleness, or purple, blotchy skin in the hours after a filler: contact the clinic that treated you straight away.
- Any change in your vision, or pain in the eye, after a facial filler: go to A&E (urgencias) or call 112.
- Swelling of the lips, tongue or throat, or difficulty breathing: call 112.
- Redness, heat and tenderness that spread or worsen in the days after treatment, with or without a temperature.
- A hard, tender or growing lump, even months after the injection.
Frequently asked
Do dermal fillers hurt?
Less than most people expect. A numbing cream is applied first and many gels contain a local anaesthetic. You feel pressure and a few sharp moments. Lips are the most sensitive area; the cheeks and chin are usually easy.
How long does a session take, and can I go back to work?
The injections take around half an hour, longer if several areas are planned. Most people go straight back to normal life. Avoid hard exercise, saunas and pressing on the area for the first 24 hours, and wear make-up from the next day.
Can I go to the beach or fly after fillers?
Flying is fine. For the first few days, avoid intense sun, heat and very hot showers, which can increase swelling. If you are flying home after the season, book treatment two to three weeks before you leave so the review can take place here.
Can fillers be combined with anti-wrinkle injections?
Yes, and they often are. Fillers restore support and volume; anti-wrinkle injections relax the muscles behind expression lines. They do different jobs. The doctor decides the order and whether both can be done on the same day.
How often will I need a top-up?
It depends on the area and the product. Many people have a smaller maintenance treatment once a year or so, before the effect has gone completely. There is no need to keep to a fixed schedule: you decide with your doctor when the face actually needs it.
Will my face look worse when the filler wears off?
No. The gel is absorbed gradually, so the area slowly returns towards how it would have looked without treatment. It does not leave the skin looser than before.
I had filler in another country and do not know what it was. Is that a problem?
Tell the doctor at your consultation, with any paperwork you have. If it might have been a permanent filler, the plan changes: hyaluronic acid should not be added on top without examining the area first, sometimes with an ultrasound scan.
What if I do not like the result?
Wait about two weeks, until the swelling has settled, and come to your review. Small imbalances can often be adjusted. If you are still unhappy, hyaluronic acid can be partly or completely dissolved at the clinic.
References
Sources checked against PubMed or Crossref. Cited as plain text, without links.
- 1.Wu GT, Kam J, Bloom JD. Hyaluronic Acid Basics and Rheology. Clin Plast Surg. 2023;50(3):391-398. doi: 10.1016/j.cps.2022.12.004. PMID: 37169405.Verified on 19 October 2026
- 2.Jones D, Murphy DK. Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study. Dermatol Surg. 2013;39(11):1602-12. doi: 10.1111/dsu.12343. PMID: 24093664.Verified on 19 October 2026
- 3.Czumbel LM, Farkasdi S, Gede N, Mikó A, Csupor D, Lukács A, et al. Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A Meta-Analysis. Front Surg. 2021;8:681028. doi: 10.3389/fsurg.2021.681028. PMID: 34422892.Verified on 19 October 2026
- 4.Trinh LN, Grond SE, Gupta A. Dermal Fillers for Tear Trough Rejuvenation: A Systematic Review. Facial Plast Surg. 2022;38(3):228-239. doi: 10.1055/s-0041-1731348. PMID: 34192769.Verified on 19 October 2026
- 5.Tamura T, Tamura T, Okumura K, Funakoshi Y, Teranishi H. Serious Complications of Hyaluronic Acid Fillers-A Retrospective Study of 290,307 Cases. Ann Plast Surg. 2025;94(6):630-633. doi: 10.1097/SAP.0000000000004327. PMID: 40358958.Verified on 19 October 2026
- 6.Kapoor KM, Kapoor P, Heydenrych I, Bertossi D. Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature. Aesthetic Plast Surg. 2020;44(3):929-944. doi: 10.1007/s00266-019-01562-8. PMID: 31822960.Verified on 19 October 2026
- 7.Urdiales-Gálvez F, Delgado NE, Figueiredo V, Lajo-Plaza JV, Mira M, Moreno A, et al. Treatment of Soft Tissue Filler Complications: Expert Consensus Recommendations. Aesthetic Plast Surg. 2018;42(2):498-510. doi: 10.1007/s00266-017-1063-0. PMID: 29305643.Verified on 19 October 2026
- 8.Sawaguchi R, Kondoh S, Kinjo Y, Yuzuriha S. Frequency and Characteristics of Delayed-Onset Inflammatory Nodules After Hyaluronic Acid Injections in Japan. Aesthetic Plast Surg. 2025;49(23):6695-6701. doi: 10.1007/s00266-025-05185-0. PMID: 40906285.Verified on 19 October 2026
Educational content. It does not replace a medical consultation or provide a diagnosis. Tests and treatments are indicated only after medical consultation and in line with regulation.